Our Chinese characters are really interesting. Some words look the same but have different meanings, while some words are completely different but refer to the same thing. For example, dwarf tea. It is not the tea we usually drink. It is a kind of herbal medicine; Aidi tea is a folk herbal medicine in the southern region. As a commonly used medicinal material, it has many effects. So what are the effects of Aidi tea decoction pieces?
Pharmacological effects of Aidi tea decoction pieces
1. Cough relieving effect: Aidi tea decoction and its extract, catechin No. 1 have obvious cough relieving effects on the cough caused by electrical stimulation of cat superior laryngeal nerve and the cough in mice caused by ammonia spray, catechin No. 1 The effect is particularly significant, which may be the main cough suppressant of Aidi tea. Its antitussive effect intensity is equivalent to 1/4 to 1/7 of cocaine according to the dose, and it is intolerable even if it is administered to cats continuously for 23 days. It is speculated that the site of antitussive effect is in the center, possibly in the midbrain. Ai Dicha and Dwarf Tea No. 1 have no effect on reducing the dose of thiopental sodium in rats, and no obvious analgesic effect on mice. Large doses have no hypnotic effect on animals. Poisoned doses have no obvious respiration inhibitory effect on dogs. Tea Suo No. 1 has no obvious resistance to respiratory excitement caused by Nicosame. The suppression of the cough center by this drug may be selective, and there is no obvious suppression of other centers.
2. Expectorant and antiasthmatic effects: Aidi tea decoction has obvious expectorant effects on mice by gavage (phenol red method), and the intensity of action is equivalent to that of platycodon grandiflorum. The effect of intraperitoneal injection is stronger, but it has a stronger effect on rabbit eyes. The binding membrane has no obvious irritation, indicating that its expectorant effect may be produced by absorption. The effective ingredient of expectorant may be flavonoid glycosides. Gum catechin No. 1 has no expectorant effect and no obvious anti-asthmatic effect (guinea pig histamine spray method).
3. Effect on respiration: Aidi tea has the effect of reducing oxygen consumption in rat trachea-lung tissue. Chloranthin No. 1 acts on the enzyme system containing essential sulfhydryl groups, thus reducing tissue respiration, but the effect is Not strong.
4. Antiviral effect: Ai Di tea decoction has a certain inhibitory effect on Staphylococcus aureus and influenza virus (chicken embryo test). After the tannin is removed, the antibacterial effect is lost; although the volatile oil and flavonoid glycosides have antibacterial effects in vitro, it is difficult to reach effective concentrations in the body.
5. Effect on bronchitis: daily inhalation of sulfur dioxide in rats with chronic bronchitis, oral administration of catechin No. 1 has certain preventive and therapeutic effects, manifested as goblet cell reduction, inflammatory cell infiltration, emphysema and lungs The degree of shrinkage is reduced.
6. In vivo processes: After oral administration of catechin No. 1 by dogs and humans, the absorption is fast but not complete; the excretion is also fast, and the original drug appears in the urine 1 hour after oral administration. After intramuscular injection of large doses in dogs, the peak blood concentration appears at 1 to 4 hours after administration, and the peak urine concentration appears at 2 to 7 hours after administration. Most of the drug excreted in the urine in its original form is excreted within 12 hours, but only accounts for 0.8-4.2% of the total dose (less than 1% of the drug dose for humans), indicating that most of the drug may be metabolized in the body , And then quickly excreted by the kidneys. Therefore, its clinical effect is quick and short.