The role and efficacy of protocatechualdehyde

It is taken from Salvia miltiorrhiza, mostly wild, and is mainly produced in Sichuan; it is beneficial to the heart and has been used in clinical practice; but it is also poisonous, and it has been wailing in mice; it is protocatechualdehyde, which is a commonly used Chinese medicine of Lamiaceae The roots of the plant Salvia miltiorrhiza are mostly wild. Sichuan is mainly cultivated. Southern Salvia and Gansu Salvia are also widely used. In addition, the roots of various plants of the same genus are used as Salvia in Yunnan; the harvest quality is better in autumn; since it is Salvia root , Why is it also called protocatechualdehyde, what are the functions and effects of protocatechualdehyde?

The role and efficacy of protocatechualdehyde

Protocatechuic aldehyde is crushed by Salvia miltiorrhiza medicinal materials, added 12 times the amount of methanol, soaked overnight, ultrasonically extracted, 3500 rpm/separation core, take the supernatant through a polyamide column, eluted with 20% alcohol, extracted with ethyl acetate, and refined. Crystal, the content is about 98%. The finished product is brown-yellow dry powder, and the pure product is white-like powder; the taste is slightly bitter and astringent, and it is hygroscopic. It is soluble in water, ethanol and methanol.

Protocatechualdehyde has a significant effect on dilating coronary arteries and increasing coronary blood flow: Protocatechualdehyde is one of the main effective components in Sijiqing leaves against angina pectoris. It can increase coronary flow and reduce myocardial excitability to the cardiovascular system. And conductivity, it has obvious protective effect on myocardial injury caused by acute myocardial ischemia and hypoxia. In the early years, the effective ingredient protocatechual, which is anti-angina pectoris, was extracted from the Chinese herbal medicine Sijiqing for the treatment of scalds, and artificially synthesized into the medicine for the treatment of coronary heart disease—Xidianan (protocatechus tablets), which has been used in clinical practice. Later, it was confirmed that the protocatechuic aldehyde in Salvia miltiorrhiza was one of the effective ingredients for promoting blood circulation and removing blood stasis.

In addition, the water-soluble components of Salvia miltiorrhiza, protocatechualdehyde and danshensu, have stronger cardio-cerebrovascular expansion effects than diterpene quinones, which are the main components of anti-myocardial ischemia. It has broad-spectrum antibacterial and anti-inflammatory effects: protocatechualdehyde is one of the main effective components of old head grass in the treatment of nephritis; it protects brain tissue from ischemia and reperfusion injury, enhances hypoxia tolerance and improves renal function.

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